Externalization of host cell protein kinase C during enteropathogenic Escherichia coli infection
نویسندگان
چکیده
منابع مشابه
Activation of host cell protein kinase C by enteropathogenic Escherichia coli.
Enteropathogenic Escherichia coli (EPEC) consists of a group of diarrhea-producing E. coli strains, common in developing countries, which do not produce classical toxins and are not truly invasive. EPEC strains adhere to mammalian cells in an intimate fashion, trigger a localized increase in intracellular calcium levels, and elevate inositol phosphate production. We hypothesized that these medi...
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Enteropathogenic Escherichia coli (EPEC) specifically recognizes phosphatidylethanolamine (PE) on the outer leaflet of host epithelial cells. EPEC also induces apoptosis in epithelial cells, which results in increased levels of outer leaflet PE and increased bacterial binding. Consequently, it is of interest to investigate whether EPEC infection perturbs host cell phospholipid metabolism and wh...
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Charles Darkoh1,2 and Herbert L. DuPont1,2,3,4,5 1Graduate School of Biomedical Sciences, Molecular Pathology Program, The University of Texas; 2The University of Texas School of Public Health, Center for Infectious Diseases; 3Department of Internal Medicine, The University of Texas Medical School; 4Internal Medicine Service, St. Luke's Episcopal Hospital; and 5Department of Medicine, Baylor Co...
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Enteropathogenic Escherichia coli (EPEC) is an important cause of diarrhea in humans. EPEC infection of cultured intestinal epithelial cells induces attaching and effacing (A/E) lesions, alters intestinal ion transport, increases paracellular permeability, and stimulates inflammation. The lack of a small-animal model has restricted in vivo studies examining EPEC-host interactions. The aim of th...
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Enteropathogenic Escherichia coli (EPEC), first described in the 1940's and 1950's, remain an important cause of severe infantile diarrhoea in many parts of the developing world. EPEC do not produce enterotoxins and are not invasive; instead their virulence depends upon exploitation of host cell signalling pathways and the host cell cytoskeleton both as a means of colonizing mucosal surfaces of...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2004
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4401531